Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia.
نویسندگان
چکیده
Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disease triggered by several anaesthetic agents. The in vitro muscle contracture test (IVCT) is the standard test to establish an individual's risk of susceptibility to MH. Clinical practitioners and geneticists of the European MH Group have agreed on the present guidelines for the detection of MH susceptibility using molecular genetic techniques and/or IVCT to predict the risk of MH.
منابع مشابه
Molecular genetic testing for malignant hyperthermia susceptibility.
BACKGROUND For more than 30 yr, the in vitro contracture test (IVCT) was the only appropriate diagnostic tool for malignant hyperthermia (MH). After the introduction of molecular genetics into MH research, guidelines for molecular genetic diagnosis of MH susceptibility were published. The aim of this study was to establish applicability of the guidelines, sensitivity, and specificity of genetic...
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Malignant hyperthermia (MH) is triggered by all inhalative anesthetics as well as depolarizing muscle relaxants in genetically predisposed individuals. Presymptomatic testing is important in this potentially fatal pharmacogenetic disease. In vitro challenging of muscle samples with halothane and caffeine is the basis of contracture testing, which until recently was the only accepted diagnostic ...
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 86 2 شماره
صفحات -
تاریخ انتشار 2001